Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles
نویسندگان
چکیده
منابع مشابه
Evaluation of antibacterial activity of new N-piperazinyl quinolone derivatives with 1,3,4.thiadiazole group
quinolones are broad-spectrum antibacterial agents.they have many clinical uses which are increasing.quinolones exert antibacterial activity primarily by inhibiting bacterial DNA gyrase.the inhibition of DNA gyrase by the quinolones are greatly influenced by the nature of the C-7 substituent on the quinolones molecule.substitution of bulky functional groupd is also possible in C-7 position.furt...
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In the last three decades investigations in the field of oxadiazoles have been intensified due to their diverse therapeutic uses. Oxadiazole are well known to have a wide range of therapeutic activities namely anti-inflammatory, analgesic, antipyretic, anticonvulsant, antiparasitic, antimicrobial etc. In this study, we have evaluated the antimicrobial activity of some carboxymethyl derivativ...
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PURPOSE The prokaryotic type II topoisomerases (DNA gyrase and topoisomerase IV) and the eukaryotic type II topoisomerases represent the cellular targets for quinolone antibacterial agents and a wide variety of anticancer drugs, respectively. In view of the mechanistic similarities and sequence homologies exhibited by the two enzymes, tentative efforts to selectively shift from an antibacterial...
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The in vitro antimicrobial activity of ciprofloxacin (Bay o 9867) was compared with those of the other new fluorated piperazinyl-substituted quinoline derivatives: norfloxacin, ofloxacin, and pefloxacin, as well as with those of the earlier analogs, nalidixic acid and oxolinic acid. Virtually no resistance against the new fluorated piperazinyl-substituted quinoline derivatives was observed. As ...
متن کاملevaluation of antibacterial and antifungal activity of some 1, 3, 4 oxadiazoles
in the last three decades investigations in the field of oxadiazoles have been intensified due to their diverse therapeutic uses. oxadiazole are well known to have a wide range of therapeutic activities namely anti-inflammatory, analgesic, antipyretic, anticonvulsant, antiparasitic, antimicrobial etc. in this study, we have evaluated the antimicrobial activity of some carboxymethyl derivatives ...
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ژورنال
عنوان ژورنال: Journal of Modern Research
سال: 2019
ISSN: 2636-3909
DOI: 10.21608/jmr.2019.12650.1001